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Title 

A novel small molecule facilitates the reprogramming of human somatic cells into a pluripotent state and supports the maintenance of an undifferentiated state of human pluripotent stem cells

Authors 

Jung Woon LeeY XiaMi Young SonG JinBinna SeolMin-Jeong KimMyung Jin SonM DoM LeeD KimK LeeYee Sook Cho

Publisher 

Wiley-Blackwell

Issue Date 

2012

Citation 

Angewandte Chemie International Edition, vol. 51, no. 50, pp. 12509-12513

Keywords 

gene expressionpluripotencyreprogrammingsmall moleculesstem cells

Abstract 

Booster of pluripotency: RSC133, a new synthetic derivative of indoleacrylic acid/indolepropionic acid, exhibits dual activity by inhibiting histone deacetylase and DNA methyltransferase. Furthermore it potently improves the reprogramming of human somatic cells into a pluripotent state and aids the growth and maintenance of human pluripotent stem cells (hPSCs).

ISSN 

1433-7851

Link 

http://dx.doi.org/10.1002/anie.201206691

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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