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Title 

CRP detection from serum for chip-based point-of-care testing system

Authors 

C H KimJ H AhnJ Y KimJ M ChoiK C LimT J ParkN S HeoHee Gu LeeJ W KimY K Choi

Publisher 

Elsevier

Issue Date 

2013

Citation 

Biosensors & Bioelectronics, vol. 41, no. 1, pp. 322-327

Keywords 

C-reactive proteinCRPFET-based biosensorNanogap-embedded FETPoint-of-care testing (POCT)

Abstract 

Most of point-of-care testing (POCT) to improve facilitates in diagnosis, treatment, and monitoring of patients. POCT technique has still remained a quantitatively and accurately detective effect. In this article, we demonstrated that real human C-reactive protein (CRP) in serum was detected for a chip-based point-of-care testing application based on a nanogap-embedded field effect transistor (FET), and the results were compared with those obtained via the enzyme-linked immunosorbent assay (ELISA) method. The limit of detection (LOD), determined from the standard curve, was 0.1. ng/ml, which is comparable to that of commercialized ELISAs. We evaluated that an improved detection range (0.1. ng/ml to 100. ng/ml) was achieved by comparing with commercialized ELISA. Control experiments to determine selectivity and to discern false-positive/false-negative rates were also performed. This report is the first description of the detection of CRP in human serum using a silicon-based biosensor.

ISSN 

0956-5663

Link 

http://dx.doi.org/10.1016/j.bios.2012.08.047

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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