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Title 

Tumor-associated autoantibodies as diagnostic and prognostic biomarkers

Authors 

Chang Gyu HeoY Y BahkEun Wie Cho

Publisher 

Korean Society for Biochemistry and Molecular Biology

Issue Date 

2012

Citation 

BMB Reports, vol. 45, no. 12, pp. 677-685

Keywords 

BiomarkerDiagnosticPrognosticTumor-associated autoantibodyTumor-associated autoantigen

Abstract 

In the process of tumorigenesis, normal cells are remodeled to cancer cells and protein expression patterns are changed to those of tumor cells. A newly formed tumor microenvironment elicits the immune system and, as a result, a humoral immune response takes place. Although the tumor antigens areundetectable in sera at the early stage of tumorigenesis, the nature of an antibody amplification response to antigens makes tumor-associated autoantibodies as promising early biomarkers in cancer diagnosis. Moreover, the recent development of proteomic techniques that make neo-epitopes of tumor-associated autoantigens discovered concomitantly has opened a new area of 'immuno-proteomics',which presents tumor-associated autoantibody signatures and confers information to redefine the process of tumorigenesis. In this article, the strategies recently used to identify and validate serumautoantibodies are outlined and tumor-associated antigens suggested until now as diagnostic/prognostic biomarkers in various tumor types are reviewed. Also, the meaning of autoantibody signatures and their clinical utility in personalized medicine are discussed.

ISSN 

1976-6696

Link 

http://dx.doi.org/10.5483/BMBRep.2012.45.12.236

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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