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Title 

Ganglioside GM1 influences the proliferation rate of mouse induced pluripotent stem cells

Authors 

J S RyuKyu Tae ChangJ T LeeM U LimH K MinY J NaS B LeeG MoussavouSun-Uk KimJi Su KimK KoK A HwangE J JeongJeong Woong LeeY K Choo

Publisher 

Korean Society for Biochemistry and Molecular Biology

Issue Date 

2012

Citation 

BMB Reports, vol. 45, no. 12, pp. 713-718

Keywords 

Cell cycleGanglioside GM1MAP kinaseMouse induced pluripotent stem cells (miPSCs)Proliferation

Abstract 

Gangliosides play important roles in the control of several biological processes, including proliferation and transmembrane signaling. In this study, we demonstrate the effect of ganglioside GM1 on the proliferation of mouse induced pluripotent stem cells (miPSCs). The proliferation rate of miPSCs was lower than in mouse embryonic stem cells (mESCs).Fluorescence activated cell sorting analysis showed that the percentage of cells in the G2/M phase in miPSCs was lower than that in mESCs. GM1 was expressed in mESCs, but not miPSCs. To confirm the role of GM1 in miPSC proliferation, miPSCs were treated with GM1. GM1-treated miPSCs exhibited increased cell proliferation and a larger number of cells in the G2/M phase. Furthermore, phosphorylation of mitogen-activated protein kinases was increased in GM1- treated miPSCs.

ISSN 

1976-6696

Link 

http://dx.doi.org/10.5483/BMBRep.2012.45.12.138

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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