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Title 

Effusanin C inhibits inflammatory responses via blocking NF-kB and MAPK signaling in monocytes

Authors 

J Y KimH S KimY J KimH K LeeJ S KimJong Soon KangJ T HongY KimB Y HwangS B Han

Publisher 

Elsevier

Issue Date 

2013

Citation 

International Immunopharmacology, vol. 15, no. 1, pp. 84-88

Keywords 

Dendritic cellEffusanin CMacrophageMAPKNF-κB

Abstract 

Effusanin C, a constituent of Isodon japonicus, has been used in oriental countries as a traditional folk medicine to treat inflammatory diseases, but its mechanism of action remains unknown. Here, we investigate the inhibitory activity of effusanin C in inflammatory monocytes. Effusanin C markedly inhibited the production of inflammatory mediators including nitric oxide, IL-1β, and TNF-α in macrophages and dendritic cells. Furthermore, molecular studies showed that effusanin C inhibited phosphorylation of p38, JNK, and ERK, degradation of IκBβ, and nuclear translocation of NF-κB p50/p65 in these cells. Taken together, these data show that effusanin C inhibits inflammatory responses by blocking NF-κB and MAPK signalings in monocytes.

ISSN 

1567-5769

Link 

http://dx.doi.org/10.1016/j.intimp.2012.11.002

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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