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Title 

Inhibition of TAK1 by kamebakaurin in dendritic cells

Authors 

J Y KimH S KimY J KimH K LeeJ S KimJong Soon KangJ T HongY KimB Y HwangS B Han

Publisher 

Elsevier

Issue Date 

2013

Citation 

International Immunopharmacology, vol. 15, no. 1, pp. 138-143

Keywords 

KamebakaurinMAPKNF-κBTAK1

Abstract 

Kamebakaurin (KA) has anti-cancer and anti-inflammatory activities through direct inhibition of DNA-binding activity of nuclear factor-kappa B (NF-κB) p50. We suggest here another molecular target of KA by the use of lipopolysaccharide-treated dendritic cells. In cell- and enzyme-based assays, KA directly inhibited autophosphorylation and kinase activity of TAK1, followed by the inhibition of TAK1-downstream signaling cascades, such as IKK phosphorylation-IκBα degradation-nuclear translocation of NF-κB, phosphorylation of MEK3/6-p38 mitogen activated protein kinase (MAPK), and MKK4/7-c-Jun N-terminal kinase MAPK. These results demonstrated that TAK1 might be the direct molecular target of KA.

ISSN 

1567-5769

Link 

http://dx.doi.org/10.1016/j.intimp.2012.11.004

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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