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Title 

Antiviral Activity of the Plant Extracts from Thuja orientalis, Aster spathulifolius, and Pinus thunbergii Against Influenza Virus A/PR/8/34

Authors 

Ji Na WonS Y LeeDae Sub SongHaryoung Poo

Publisher 

The Korean Society for Applied Microbiology

Issue Date 

2013

Citation 

Journal of Microbiology and Biotechnology, vol. 23, no. 1, pp. 125-130

Keywords 

Antiviral activityCytopathic effectInfluenza A virusPlant extract

Abstract 

Influenza viruses cause significant morbidity and mortality in humans through epidemics or pandemics. Currently, two classes of anti-influenza virus drugs, M2 ion-channel inhibitors (amantadin and rimantadine) and neuraminidase inhibitors (oseltamivir and zanamivir), have been used for the treatment of the influenza virus infection. Since the resistance to these drugs has been reported, the development of a new antiviral agent is necessary. In this study, we examined the antiviral efficacy of the plant extracts against the influenza A/PR/8/34 infection. In vitro, the antiviral activities of the plant extracts were investigated using the cell-based screening. Three plant extracts, Thuja orientalis, Aster spathulifolius, and Pinus thunbergii, were shown to induce a high cell viability rate after the infection with the influenza A/PR/8/34 virus. The antiviral activity of the plant extracts also increased as a function of the concentration of the extracts and these extracts significantly reduced the visible cytopathic effect caused by virus infections. Furthermore, the treatment with T. orientalis was shown to have a stronger inhibitory effect than that with A. spathulifolius or P. thunbergii. These results may suggest that T. orientalis has anti-influenza A/PR/8/34 activity.

ISSN 

1017-7825

Link 

http://dx.doi.org/10.4014/jmb.1210.10074

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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