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Title 

Plasma homocysteine level and hepatic sulfur amino acid metabolism in mice fed a high-fat diet

Authors 

K U YunC S RyuJ M OhC H KimK S LeeChul Ho LeeHyun Sun LeeB H KimS K Kim

Publisher 

Springer Verlag (Germany)

Issue Date 

2013

Citation 

European Journal of Nutrition, vol. 52, no. 1, pp. 127-134

Keywords 

Hepatic steatosisHigh-fat dietHomocysteineObesitySulfur amino acid metabolism

Abstract 

Purpose: Obesity, a feature of metabolic syndrome, is a risk factor for cardiovascular disease, and elevated plasma homocysteine is associated with increased cardiovascular risk. However, little published information is available concerning the effect of obesity on homocysteine metabolism. Methods: Hepatic homocysteine metabolism was determined in male C57BL/6 mice fed a high-fat diet for 12 weeks. Results: High-fat diet increased plasma homocysteine but decreased hepatic homocysteine levels. Hepatic S-adenosylhomocysteine hydrolase levels were down-regulated in the obese mice, which was in part responsible for the decrease in hepatic S-adenosylmethionine/S- adenosylhomocysteine, which served as an index of transmethylation potential. Despite the decrease in hepatic cysteine, hepatic taurine synthesis was activated via up-regulation of cysteine dioxygenase. Hepatic levels of methionine adenosyltransferase I/III, methionine synthase, methylene tetrahydrofolate reductase, and gamma-glutamylcysteine ligase catalytic subunit were unchanged. Obese mice showed elevated betaine-homocysteine methyltransferase and decreased cystathionine beta-synthase activities, although the quantities of these enzymes were unchanged. Conclusion: This study suggests that plasma homocysteine level is increased in obesity-associated hepatic steatosis, possibly as a result of increased hepatic homocysteine efflux along with an altered sulfur amino acid metabolism.

ISSN 

1436-6207

Link 

http://dx.doi.org/10.1007/s00394-011-0294-0

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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