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Title 

STK295900, a dual inhibitor of topoisomerase 1 and 2, induces G2 arrest in the absence of DNA damage

Authors 

Sun Ok KimK SakchaisriN R ThimmegowdaNak Kyun SoungJae-Hyuk JangY S KimK S LeeY T KwonY AsamiJong Seog AhnR EriksonBo Yeon Kim

Publisher 

Public Library of Science

Issue Date 

2013

Citation 

Plos One, vol. 8, no. 1, pp. e53908-e53908

Abstract 

STK295900, a small synthetic molecule belonging to a class of symmetric bibenzimidazoles, exhibits antiproliferative activity against various human cancer cell lines from different origins. Examining the effect of STK295900 in HeLa cells indicates that it induces G2 phase arrest without invoking DNA damage. Further analysis shows that STK295900 inhibits DNA relaxation that is mediated by topoisomerase 1 (Top 1) and topoisomerase 2 (Top 2) in vitro. In addition, STK295900 also exhibits protective effect against DNA damage induced by camptothecin. However, STK295900 does not affect etoposide-induced DNA damage. Moreover, STK295900 preferentially exerts cytotoxic effect on cancer cell lines while camptothecin, etoposide, and Hoechst 33342 affected both cancer and normal cells. Therefore, STK295900 has a potential to be developed as an anticancer chemotherapeutic agent.

ISSN 

1932-6203

Link 

http://dx.doi.org/10.1371/journal.pone.0053908

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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