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Title 

2-Hydroxycinnamaldehyde inhibits the epithelial-mesenchymal transition in breast cancer cells

 

하이드록시 신남알데하이드에 의한 암 전이 억제 기전 규명

Authors 

I A IsmailH S KangH J LeeH ChangJi Eun YunChang Woo LeeN H KimH S kimJ I YookS H HongByoung-Mog Kwon

Publisher 

Springer Verlag (Germany)

Issue Date 

2013

Citation 

Breast Cancer Research and Treatment, vol. 137, no. 3, pp. 697-708

Keywords 

2′-HydroxycinnamaldehydeBreast cancer cellsCell invasionEpithelial-mesenchymal transition (EMT)KLF17Snail --------------------------------------------------------------------------------

Abstract 

Since epithelial-mesenchymal transition (EMT) plays a critical role in cancer progression and in maintaining cancer stem cell properties, EMT is emerging as a therapeutic target for inhibiting the metastatic progression of cancer cells. 2′-Hydroxycinnamaldehyde (HCA) and its derivative, 2′-benzoyloxycinnamaldehyde, have recently been suggested as promising therapeutic candidates for cancer treatment. The purpose of this study is to investigate the anti-metastatic effect of HCA on breast cancer and the molecular mechanisms by which HCA regulates the transcriptional program during EMT. HCA induces epithelial reversion at nanomolar concentrations by suppressing Snail via the nuclear translocalization of GSK-3β, which results in the transcriptional upregulation of E-cadherin. HCA also activates the transcription factor KLF17, which suppresses Id-1, indicating that HCA inhibits EMT by multiple transcriptional programs. Further, HCA treatment significantly inhibits lung metastasis in a mouse orthotopic breast cancer model. This study demonstrates the anti-metastatic effect of the non-toxic natural compound HCA through attenuation of EMT in a breast cancer model.

ISSN 

0167-6806

Link 

http://dx.doi.org/10.1007/s10549-012-2388-7

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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