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Title 

Saponins, especially platycodin D, from Platycodon grandiflorum modulate hepatic lipogenesis in high-fat diet-fed rats and high glucose-exposed HepG2 cells

Authors 

Y P HwangJ H ChoiH G KimT KhanalG Y SongM S NamHyun Sun LeeY C ChungY C LeeH G Jeong

Publisher 

Elsevier

Issue Date 

2013

Citation 

Toxicology and Applied Pharmacology, vol. 267, no. 0, pp. 174-183

Keywords 

AMPKLipogenesisPlatycodin DPlatycodon grandiflorum

Abstract 

AMP-activated protein kinase (AMPK) plays a central role in controlling hepatic lipid metabolism through modulating the downstream acetyl CoA carboxylase (ACC) and sterol regulatory element-binding protein-1c (SREBP-1c) pathway. Saponins, particularly platycodin D, from the roots of Platycodon grandiflorum (Changkil saponins, CKS) have a variety of pharmacological properties, including antioxidant and hepatoprotective properties. The aim of this study was to investigate the effects of CKS on hepatic lipogenesis and on the expression of genes involved in lipogenesis, and the mechanisms involved. CKS attenuated fat accumulation and the induction of the lipogenic genes encoding SREBP-1c and fatty acid synthase in the livers of HFD-fed rats and in steatotic HepG2 cells. Blood biochemical analyses and histopathological examinations showed that CKS prevented liver injury. CKS and platycodin D each increased the phosphorylation of AMPK and acetyl-CoA carboxylase in HFD-fed rats and HepG2 cells. The use of specific inhibitors showed that platycodin D activated AMPK via SIRT1/CaMKKβ in HepG2 cells. This study demonstrates that CKS or platycodin D alone can regulate hepatic lipogenesis via an AMPK-dependent signalling pathway.

ISSN 

0041-008X

Link 

http://dx.doi.org/10.1016/j.taap.2013.01.001

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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