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Title 

MENT: Methylation and expression database of normal and tumor tissues

Authors 

Su Jin BaekS YangT W KangSeong-Min ParkYong Sung KimSeon-Young Kim

Publisher 

Elsevier

Issue Date 

2013

Citation 

Gene, vol. 518, no. 1, pp. 194-200

Keywords 

CancerDNA methylationGene expression

Abstract 

Integrated analysis of DNA methylation and gene expression can reveal specific epigenetic patterns that are important during carcinogenesis. We built an integrated database of DNA methylation and gene expression termed MENT (Methylation and Expression database of Normal and Tumor tissues) to provide researchers information on both DNA methylation and gene expression in diverse cancers. It contains integrated data of DNA methylation, gene expression, correlation of DNA methylation and gene expression in paired samples, and clinicopathological conditions gathered from the GEO (Gene Expression Omnibus) and TCGA (The Cancer Genome Atlas). A user-friendly interface allows users to search for differential DNA methylation by either 'gene search' or 'dataset search'. The 'gene search' returns which conditions are differentially methylated in a gene of interest, while 'dataset search' returns which genes are differentially methylated in a condition of interest based on filtering options such as direction, DM (differential methylation value), and p-value. MENT is the first database which provides both DNA methylation and gene expression information in diverse normal and tumor tissues. Its user-friendly interface allows users to easily search and view both DNA methylation and gene expression patterns. MENT is freely available at http://mgrc.kribb.re.kr:8080/MENT/.

ISSN 

0378-1119

Link 

http://dx.doi.org/10.1016/j.gene.2012.11.032

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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