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Title 

Peptidomimetic small-molecule compounds promoting cardiogenesis of stem cells

Authors 

S W OhJ B LeeB KimS JeonM K KimKi Hoan NamJ R HaM BhatiaG T OhD Y Kim

Publisher 

Pharmaceutical Society of Korea

Issue Date 

2012

Citation 

Archives of Pharmacal Research, vol. 35, no. 11, pp. 1979-1988

Keywords 

CardiogenesisEmbryonic stem cellsIschemic heart diseasePeptidomimetic compounds

Abstract 

Embryonic stem (ES) cells may be used as an alternative source of functionally intact cardiomyocytes for ischemic heart disease. Several natural and synthetic small molecules have been identified as useful tools for controlling and manipulating stem cell renewal and differentiation. Currently, there is an urgent requirement for novel small molecules that specifically induce differentiation of stem cells into cardiomyocytes. To identify compounds that promote cardiomyogenesis of stem cells, cell-based screening of a peptidomimetic small-molecule library was carried out. A series of β-turn peptidomimetic compounds, including CW209E, increased the expression of α-MHC promoter-driven enhanced green fluorescent protein (EGFP) and ratio of beating embryoid bodies (EBs) without inducing cytotoxicity in mouse embryonic stem cells. CW209E also increased the number of beating EBs in human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs). Thus, this chemical compound should be useful for elucidation of the molecular pathway of cardiogenesis and generation of cardiomyocytes ex vivo, which can be further applied for experimental or clinical cell therapy for ischemic heart diseases.

ISSN 

0253-6269

Link 

http://dx.doi.org/10.1007/s12272-012-1115-6

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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