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Title 

Design and development of synthetic microbial platform cells for bioenergy

 

합성 미생물 플랫폼 디자인 개발

Authors 

Sang Jun LeeS J LeeD W Lee

Publisher 

Frontiers Research Foundation

Issue Date 

2013

Citation 

Frontiers in Microbiology, vol. 4, no. 0, pp. 92-92

Keywords 

BioenergyGenome reductionMetabolic engineeringMicrobial platform cellsSynthetic biology

Abstract 

The finite reservation of fossil fuels accelerates the necessity of development of renewable energy sources. Recent advances in synthetic biology encompassing systems biology and metabolic engineering enable us to engineer and/or create tailor made microorganisms to produce alternative biofuels for the future bio-era. For the efficient transformation of biomass to bioenergy, microbial cells need to be designed and engineered to maximize the performance of cellular metabolisms for the production of biofuels during energy flow. Toward this end, two different conceptual approaches have been applied for the development of platform cell factories: forward minimization and reverse engineering. From the context of naturally minimized genomes,non-essential energy-consuming pathways and/or related gene clusters could be progressively deleted to optimize cellular energy status for bioenergy production. Alternatively, incorporation of non-indigenous parts and/or modules including biomass-degrading enzymes, carbon uptake transporters, photosynthesis, CO2 fixation, and etc. into chassis microorganisms allows the platform cells to gain novel metabolic functions for bioenergy. This review focuses on the current progress in synthetic biology-aided pathway engineering in microbial cells and discusses its impact on the production of sustainable bioenergy.

ISSN 

1664-302x

Link 

http://dx.doi.org/10.3389/fpsyt.2013.00092

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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