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Title 

Davallialactone protects against acetaminophen overdose-induced liver injuries in mice

Authors 

Jung Ran NohYong Hoon KimJung Hwan HwangGil Tae GangKyoung Shim KimI K LeeB S YunChul Ho Lee

Publisher 

Elsevier

Issue Date 

2013

Citation 

Food and Chemical Toxicology, vol. 28, no. 1, pp. 14-21

Keywords 

AcetaminophenDavallialactoneLiverOxidative stressToxicity

Abstract 

Oxidative stress is closely associated with acetaminophen (APAP)-induced toxicity. Davallialactone (DAVA), a hispidin analog derived from the mushroom Inonotus xeranticus, has antioxidant properties. This study evaluated whether DAVA plays protective roles against APAP hepatotoxicity in mice. Pretreatments with DAVA (10. mg/kg) prior to exposures of mice to a hepatotoxic dose of 600. mg/kg APAP significantly increased survival rate compared to APAP alone. To verify this effect, mice were treated with 400. mg/kg APAP 30. min after DAVA administration and were then sacrificed after 0.5, 1, 3, and 6. h. APAP alone caused severe liver injuries as characterized by increased plasma GOT and GPT levels, ATP and GSH depletion, and peroxynitrite and 4-HNE formations. These liver damages induced by APAP were significantly attenuated by DAVA pretreatments. The GSH/GSSG ratio nearly recovered to the levels observed in non-APAP-treated mice at 6. h after APAP treatment in DAVA-pretreated mice. Furthermore, while hepatic ROS levels were increased by APAP exposures, pretreatments with DAVA completely blocked ROS formation. In addition, APAP-induced sustained activations of JNK and ERK were remarkably reduced by DAVA pretreatment. In conclusion, these results suggest that DAVA plays protective roles against APAP-mediated hepatotoxicity through function as ROS scavenger.

ISSN 

0278-6915

Link 

http://dx.doi.org/10.1016/j.fct.2013.04.005

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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