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Title 

Bifunctional nanoparticles constructed using one-pot encapsulation of a fluorescent polymer and magnetic (Fe3O4) nanoparticles in a silica shell

Authors 

Chang-Soo LeeH H ChangPan Kee BaeJuyeon JungBong Hyun Chung

Publisher 

Wiley-Blackwell

Issue Date 

2013

Citation 

Macromolecular Bioscience, vol. 13, no. 3, pp. 321-331

Keywords 

BioimagingFluorescent polymersMultifunctional materialsTumor targeting

Abstract 

Integration of biocompatible silica with a fluorescent polymer (PDDF) and superparamagnetic iron oxide nanoparticles (Fe3O4) to form uniform core-shell nanostructures has the great potential to form particles for use in multimodal bioimaging applications. Core-shell nanoparticles (PDDF/Fe3O4@SiO2) exhibit fluorescent and magnetic properties that are favorable for their use in magnetic separation and guiding applications, as well as optical and magnetic resonance (MR) imaging capabilities. With the biological analysis in an in vitro intracellular permeation and cytotoxicity test, chemical conjugation of the surface using folic acid (FA) molecules can provide the nanoparticles with cell-targeting properties, localizing the nanoparticles to folate receptors (FRs) on target KB cells that over-express the FRs.

ISSN 

1616-5187

Link 

http://dx.doi.org/10.1002/mabi.201200308

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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