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Title 

Differential anti-inflammatory and analgesic effects by enantiomers of zaltoprofen in rodents

Authors 

Ik Jun JoChang Woo LeeMyeong Youl LeeMoo Rim KangJi Eun YunSoo Jin OhS B HanK LeeS K ParkH M KimS H JungJong Soon Kang

Publisher 

Elsevier

Issue Date 

2013

Citation 

Immunopharmacology, vol. 16, no. 4, pp. 457-460

Keywords 

AnalgesicAnti-inflammatoryEnantiomerZaltoprofen

Abstract 

In the present study, we investigated the effect of zaltoprofen enantiomers on inflammation and pain and compared their effect with racemic zaltoprofen. S(+)-zaltoprofen potently inhibited the inflammatory response in carrageenan-induced paw edema model, whereas R(-)-zaltoprofen did not. Moreover, the anti-inflammatory effect of S(+)-zaltoprofen was stronger than that of racemic zaltoprofen, suggesting that S(+)-zaltoprofen is an active component of racemic zaltoprofen in terms of anti-inflammatory activity. In contrast, the results of acetic acid-induced writhing model demonstrated that no significant analgesic effect was observed by racemic zaltoprofen and zaltoprofen enantiomers at doses used in carrageenan-induced paw edema model. However, racemic zaltoprofen and zaltoprofen enantiomers all exerted an analgesic effect at higher doses, which is inconsistent with the result of carrageenan-induced paw edema model. Gastric ulcers induced by racemic zaltoprofen and zaltoprofen enantiomers were minimal. Taken together, these results suggest that S(+)-zaltoprofen is a potent and active anti-inflammatory component of racemic zaltoprofen, but both S(+)-zaltoprofen and R(-)-zaltoprofen might seem to contribute to the analgesic effect of racemic zaltoprofen.

ISSN 

0162-3109

Link 

http://dx.doi.org/10.1016/j.intimp.2013.05.008

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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