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Title 

Triterpenes with cytotoxicity from the leaves of Vernicia fordii

 

유동잎의 세포독성을 갖는 트리테르펜 화합물

Authors 

Y H PeiOk-Kyoung KwonJ S LeeH J ChaKyung Seop AhnSei-Ryang OhHyeong Kyu LeeY W Chin

Publisher 

Pharmaceutical Society of Japan

Issue Date 

2013

Citation 

Chemical & Pharmaceutical Bulletin, vol. 61, no. 6, pp. 674-677

Keywords 

CytotoxicityTriterpeneVernicia fordii

Abstract 

Two new triterpenes, (1α,3β,8α,9β,10α, 13α,14β)-9,10-dimethyl-25,26-dinorolean-5-en-1,3-diol (1) and (1α,3β,6β)-olean-12-en-1,3,6-triol (2) were isolated from the leaves of Aleurites fordii, together with five known triterpenes. The structures of isolates were established by one dimensional (1D)- and 2D-NMR spectroscopic data along with MS analysis. Of the isolated compounds, 1, 2 and 4 (daturadiol) displayed moderate cytotoxicities against two or more human cancer cell lines in HepG2 (hepatocellular carcinoma), SK-OV-3 (ovarian carcinoma), A-549 (lung carcinoma) and SNU-1 (gastric carcinoma).

ISSN 

0009-2363

Link 

http://dx.doi.org/10.1248/cpb.c13-00055

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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