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Title 

Bimodal perfluorocarbon nanoemulsions for nasopharyngeal carcinoma targeting

Authors 

Pan Kee BaeJuyeon JungS J LimD KimS K KimBong Hyun Chung

Publisher 

Springer Verlag (Germany)

Issue Date 

2013

Citation 

Molecular Imaging and Biology, vol. 15, no. 4, pp. 401-410

Keywords 

19F-MRBimodal nanoemulsionCancerCancer-specific imagingMRIOptical imagingPerfluorocarbon

Abstract 

Purpose: The aim of this study was to perform the detection of folate receptor (FR)-positive tumors with a bimodal imaging contrast agent, a perfluorocarbon (PFC)/rhodamine nanoemulsion, providing both 19F-based magnetic resonance imaging (MRI) and fluorescence imaging capabilities. Procedures: The PFC/rhodamine nanoemulsion was further infused with phospholipid-anchored folate to improve the ability to target FR-expressing tumors. The preferential accumulation of the FR-targeted bimodal nanoemulsion in FR-positive tumor sites was monitored by both 19F-MRI and optical imaging. Results: The FR-targeted PFC nanoemulsion had no significant effect on cell viability, and the size and fluorescence signal of PFC nanoemulsion were very stable. These nanoprobes were successfully delivered into FR-positive tumor xenograft models and showed significantly enhanced signal intensities of 19F-MRI and fluorescence imaging in the tumor area. Conclusions: The folate-PFC/rhodamine nanoemulsion has a great potential to serve as a useful optical and 19F-MRI agent for the diagnosis and targeting of FR-positive tumor.

ISSN 

1536-1632

Link 

http://dx.doi.org/10.1007/s11307-013-0622-2

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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