상세 정보

underline
Metadata Downloads : dc(xml) or Excel
Cited 0 time in scopus ci

Title 

Selective small molecule probes for the hypoxia inducible factor (HIF) Prolyl Hydroxylases

Authors 

R ChowdhuryJ I Candela-LenaM C ChanD J GreenaldK K YeohY M TianM A McDonoughA TumberN R RoseA Conejo-GarciaM DemetriadesS MathavanA KawamuraMyung Kyu LeeF EedenC W PughP J RatcliffeC J Schofield

Publisher 

American Chemical Society

Issue Date 

2013

Citation 

ACS Chemical Biology, vol. 8, no. 7, pp. 1488-1496

Abstract 

The hypoxia inducible factor (HIF) system is central to the signaling of low oxygen (hypoxia) in animals. The levels of HIF-α isoforms are regulated in an oxygen-dependent manner by the activity of the HIF prolyl-hydroxylases (PHD or EGLN enzymes), which are Fe(II) and 2-oxoglutarate (2OG) dependent oxygenases. Here, we describe biochemical, crystallographic, cellular profiling, and animal studies on PHD inhibitors including selectivity studies using a representative set of human 2OG oxygenases. We identify suitable probe compounds for use in studies on the functional effects of PHD inhibition in cells and in animals.

ISSN 

1554-8929

Link 

http://dx.doi.org/10.1021/cb400088q

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


There are no files associated with this item.
qrcode

FusionCharts.
DSpace Software Coptright(c) 2010 MIT and Hewleft-Packard  /  KRIBB-REPOSITORY ( Email:jakim@kribb.re.kr)