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Title 

Identification and characterisation of coumarins from the roots of Angelica dahurica and their inhibitory effects against cholinesterase

Authors 

W D SeoJ Y KimHyung Won RyuJ H KimS I HanJ E RaK H SeoK C JangJ H Lee

Publisher 

Journal of Functional Foods

Issue Date 

2013

Citation 

Journal of Functional Foods, vol. 5, no. 3, pp. 1421-1431

Keywords 

AcetylcholinesteraseAngelica dahuricaButylcholinesteraseCoumarinRootUltra performance liquid chromatography

Abstract 

The current research was the first to investigate coumarins and their cholinesterase inhibitory activities from Angelica dahurica roots. The ethanol extract of this species (100μg/ml) possessed inhibitory effects against human acetylcholinesterase (hAChE) and butylcholinesterase (BChE) with IC50 values of 26.40 and 14.71μg/ml, respectively. To evaluate the compounds responsible for these activities, the ethanol extract was chromatographed, which yielded ten coumarins, including isoimperatorin (1), imperatorin (2), senbyakangelicol (3), oxypeucedanin (4), byakangelicol (5), t-OMe-oxypeucedanin hydrate (6), t-OMe-byakangelicin (7), angelol H (8), byakangelicin (9), and oxypeucedanin hydrate (10). Among them, coumarin 5, 7, and 9 showed potent inhibition with IC50s of 46.3, 39.0, and 55.4μM (hAChE) as well as 45.2, 25.6, and 42.4μM (BChE), respectively. Moreover, their inhibition modes against two cholinesterases exhibited noncompetitive. The individual coumarin contents were remarkable differences, especially, oxypeucedanin (4) was the most predominant compound (8710.9μg/g), representing approximately 55.0% of the total content.

ISSN 

1756-4646

Link 

http://dx.doi.org/10.1016/j.jff.2013.05.011

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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