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Title 

Candidate target genes for the Saccharomyces cerevisiae transcription factor, Yap2

Authors 

Seo Young BangJeong Hoon KimPhil Young LeeSeung-Wook ChiS ChoG S YiP K MyungByoung Chul ParkKwang-Hee BaeSung Goo Park

Publisher 

Springer Verlag (Germany)

Issue Date 

2013

Citation 

Folia Microbiologica, vol. 58, no. 5, pp. 403-408

Keywords 

Saccharomyces cerevisiae

Abstract 

In Saccharomyces cerevisiae, the Yap family of basic leucine zipper (bZip) proteins contains eight members. The Yap family proteins are implicated in a variety of stress responses; among these proteins, Yap1 acts as a major regulator of oxidative stress responses. However, the functional roles of the remaining Yap family members are poorly understood. To elucidate the function of Yap2, we mined candidate target genes of Yap2 by proteomic analysis. Among the identified genes, FRM2 was previously identified as a target gene of Yap2, which confirmed the validity of our screening method. YNL134C and YDL124W were also identified as candidate Yap2 target genes. These genes were upregulated in strains overexpressing Yap2 and possess Yap2 target sequences in their promoter regions. Furthermore, chromatin immunoprecipitation assays showed that YNL134C and YDL124W have Yap2 binding motif. These data will help to elucidate the functional role of Yap2.

ISSN 

0015-5632

Link 

http://dx.doi.org/10.1007/s12223-013-0224-z

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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