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Title 

A known expressed sequence tag, BM742401, is a potent lincRNA inhibiting cancer metastasis

Authors 

Seong-Min ParkS J ParkHee Jin KimOh Hyung KwonT W KangHyun Ahm SohnSeon-Kyu KimS M NohK S SongS J JangYong Sung KimSeon-Young Kim

Publisher 

Korean Society of Medical Biochemistry

Issue Date 

2013

Citation 

Experimental and Molecular Medicine, vol. 45, no. 0, pp. e31-e31

Keywords 

Gastric cancerHigh-throughput RNA sequencingLong intergenic non-coding RNANon-coding RNARNA-seq

Abstract 

Long intergenic non-coding RNAs (lincRNAs) have historically been ignored in cancer biology. However, thousands of lincRNAs have been identified in mammals using recently developed genomic tools, including microarray and high-throughput RNA sequencing (RNA-seq). Several of the lincRNAs identified have been well characterized for their functions in carcinogenesis. Here we performed RNA-seq experiments comparing gastric cancer with normal tissues to find differentially expressed transcripts in intergenic regions. By analyzing our own RNA-seq and public microarray data, we identified 31 transcripts, including a known expressed sequence tag, BM742401. BM742401 was downregulated in cancer, and its downregulation was associated with poor survival in gastric cancer patients. Ectopic overexpression of BM742401 inhibited metastasis-related phenotypes and decreased the concentration of extracellular MMP9. These results suggest that BM742401 is a potential lincRNA marker and therapeutic target.

ISSN 

1226-3613

Link 

http://dx.doi.org/10.1038/emm.2013.59

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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