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Title 

Protective effect of hesperidin, a citrus flavanoglycone, against gamma-radiation-induced tissue damage in Sprague-Dawley rats

Authors 

P PradeepKyong Cheol KoM H ChoiJ A KangY J ChungS H Park

Publisher 

Mary Ann Liebert

Issue Date 

2012

Citation 

Journal of Medicinal Food, vol. 15, no. 5, pp. 419-427

Keywords 

c-radiationhesperidinlipid peroxidationradioprotection

Abstract 

The present study was designed to evaluate the radioprotective effect of hesperidin, a citrus flavanoglycone, against γ-radiation-induced cellular damage in the liver, heart, and kidney of rats. Whole-body γ-radiation exposure (5 Gy) of healthy adult rats resulted in cellular damage and oxidative stress manifested as increased levels of serum marker enzymes, lipid peroxidation, and fibrosis in the tissues, accompanied by depletion of cellular glutathione and abnormal alteration in the levels of lysosomal enzymes. Treatment with hesperidin (50 and 100 mg/kg, p.o.) for 7 days was found to offer significant protection against γ-radiation-induced toxicity in the tissues, which was evident by the improved status of most of the parameters investigated. Further, the histological examination of periodic acid-Schiff-stained tissue sections of animals treated with hesperidin following radiation exposure showed minimal necrotic damage with a recovery pattern in a dose-dependent manner compared with radiation-exposed animals. The results of our study show that administration of hesperidin offers effective protection against γ-radiation-induced cellular damage and oxidative stress in rats.

ISSN 

1096-620X

Link 

http://dx.doi.org/10.1089/jmf.2011.1737

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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