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Title 

Discovery of novel 2-hydroxydiarylamide derivatives as TMPRSS4 inhibitors

Authors 

Sunghyun KangHye-Jin MinM S KangM G JungSemi Kim

Publisher 

Elsevier

Issue Date 

2013

Citation 

Bioorganic & Medicinal Chemistry Letters, vol. 23, no. 6, pp. 1748-1751

Keywords 

2-HydroxydiarylamideAntitumorInvasionTMPRSS4 inhibitors

Abstract 

TMPRSS4 is a novel type II transmembrane serine protease that has been implicated in the invasion and metastasis of colon cancer cells. In this study, a novel series of 2-hydroxydiarylamide derivatives were synthesized and evaluated for inhibiting TMPRSS4 serine protease activity and suppressing cancer cell invasion. These derivatives demonstrated good inhibitory activity against TMPRSS4 serine protease, which correlated with the promising anti-invasive activity of colon cancer cells overexpressing TMPRSS4.

ISSN 

0960-894X

Link 

http://dx.doi.org/10.1016/j.bmcl.2013.01.055

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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