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Title 

Enhanced antioxidant and protective activities on retinal ganglion cells of carotenoids-overexpressing transgenic carrot

Authors 

K D YoonS N KangJ Y BaeHaeng Soon LeeSang Soo KwakI JangI S KimC H LeeJ M BaeS W LeeM J Ahn

Publisher 

Bentham Science Publishers

Issue Date 

2013

Citation 

Current Drug Targets, vol. 14, no. 9, pp. 999-1005

Keywords 

Antioxidant activityCarotenoidsRGC-5 cellsTransgenic carrot

Abstract 

Carotenoids are considered to act as antioxidants and protect humans from serious disorders such as skin degeneration and ageing, cardiovascular disease, certain types of cancer, and age-related diseases of the eye. In this study, these chemopreventive activities of a carotenoids-overexpressing transgenic carrot were evaluated. The results of DPPH, hydroxyl, and superoxide radical scavenging tests demonstrate that the acetone extract obtained from the taproots of the carrot plants exhibits significant antioxidant activity. A higher activity was detected in the transgenic carrot extract compared with the wild-type extract. A chemopreventive activity test for degenerative diseases of the eye revealed that pretreatment with the carrot extract reduced cell death in a retinal ganglion cell line, RGC-5 cells exposed to 1-buthionine- (R,S)-sulfoximine and L-glutamic acid.

ISSN 

1389-4501

Link 

http://dx.doi.org/10.2174/1389450111314090008

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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