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Title 

RecA-mediated SOS response provides a geraniol tolerance in Escherichia coli

Authors 

A A ShahC WangS H YoonJ Y KimEui Sung ChoiS W Kim

Publisher 

Elsevier

Issue Date 

2013

Citation 

Journal of Biotechnology, vol. 167, no. 4, pp. 357-364

Keywords 

DNA repairEscherichia coliGeraniolRecASOS responseStress tolerance

Abstract 

Geraniol is an important industrial material and a potential candidate of advanced biofuels. One challenge of microbial geraniol production is the toxicity to hosts. However, the poor understanding on geraniol tolerance mechanism is an obstacle for developing geraniol tolerant host. This study genome-widely screened a shot-gun DNA library of Escherichia coli and found that recA is able to confer geraniol tolerance in E. coli. The recA knockout mutant was found extremely sensitive to geraniol. Based on our data, it was deciphered that recA provided tolerance through SOS response network responding to DNA damage caused by geraniol. RecA-mediated SOS response activates the homologous recombinational repair by RecB and RecN for corrective DNA maintenance. This protection mechanism suggests an effective strategy to combat geraniol toxicity in E. coli.

ISSN 

0168-1656

Link 

http://dx.doi.org/10.1016/j.jbiotec.2013.07.023

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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