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Title 

A chrysin derivative suppresses skin cancer growth by inhibiting cyclin-dependent kinases

Authors 

H LiuK LiuZ HuangChan-Mi ParkN R ThimmegowdaJae-Hyuk JangInJa RyooL HeSun Ok KimN OiK W LeeNak Kyun SoungA M BodeY YangX ZhouR L EriksonJong Seog AhnJoonsung HwangK E KimZ DongBo Yeon Kim

Publisher 

American Society for Biochemistry and Molecular Biology

Issue Date 

2013

Citation 

Journal of Biological Chemistry, vol. 288, no. 36, pp. 25924-25937

Abstract 

Background: Binding to the ATP site results in poor selectivity; therefore, development of ATP-noncompetitive inhibitors is needed. Results: A modified chrysin with anticancer activity targets Cdks and binds to a Cdk2 allosteric site, not the ATP pocket. Conclusion: Modified chrysin is a novel ATP-noncompetitive inhibitor. Significance: This pharmacophore model might provide insights for the development of new ATP-noncompetitive agents

ISSN 

0021-9258

Link 

http://dx.doi.org/10.1074/jbc.M113.464669

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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