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Title 

Cytotoxic psammaplysin analogues from a Suberea sp. marine sponge and the role of the spirooxepinisoxazoline in their activity

Authors 

Y J LeeS HanH S LeeJong Soon KangJi Eun YunC J SimH J ShinJ S Lee

Publisher 

American Chemical Society

Issue Date 

2013

Citation 

Journal of Natural Products, vol. 76, no. 9, pp. 1731-1736

Abstract 

Seventeen bromotyrosine-derived metabolites, including eight new compounds, were isolated from a Micronesian sponge of the genus Suberea. Four of the new compounds were psammaplysin derivatives (10-13), and the other four were ceratinamine derivatives (14-17). Of the compounds obtained, the psammaplysins exhibited cytotoxicity against human cancer cell lines (GI50 values down to 0.8 μM), while the ceratinamine and moloka'iamine analogues showed almost no activity. These results suggest that the spirooxepinisoxazoline ring system is a requirement for cytotoxicity and, therefore, may serve as an attractive molecular scaffold for the development of a potent anticancer agent.

ISSN 

0163-3864

Link 

http://dx.doi.org/10.1021/np400448y

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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