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Title 

Identification of malate dehydrogenase 2 as a target protein of the HIF-1 inhibitor LW6 using chemical probes

Authors 

K LeeHyun Seung BanR NaikYe Seul HongS SonBo Kyung KimY XiaK B SongH S LeeMi Sun Won

Publisher 

Wiley-Blackwell

Issue Date 

2013

Citation 

Angewandte Chemie International Edition, vol. 52, no. 39, pp. 10286-10289

Keywords 

click chemistryfluorescent probesHIF inhibitorsmalate dehydrogenase 2photoaffinity labeling

Abstract 

Tracking the target: To identify a protein that binds directly to the HIF-1α inhibitor LW6, a series of new chemical probes were synthesized with a clickable tag and/or a photoactivatable moiety. LW6 was found to be localized to the mitochondria (see picture) and MDH2 was identified as a target protein of LW6. These results indicate that the HIF-1α inhibitory activity of LW6 is a consequence of MDH2 suppression.

ISSN 

1433-7851

Link 

http://dx.doi.org/10.1002/anie.201304987

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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