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Title 

The natural compound cantharidin induces cancer cell death through inhibition of heat shock protein 70 and Bcl-2-associated athanogene domain 3 expression by blocking heat shock factor 1 binding to promoters

 

HSF1 promoter 결합 저해로 HSP70과 BAG3 억제

Authors 

Joo Ae KimYoungmi KimByoung-Mog KwonDong Cho Han

Publisher 

American Society for Biochemistry and Molecular Biology

Issue Date 

2013

Citation 

Journal of Biological Chemistry, vol. 288, no. 40, pp. 28713-28726

Abstract 

Background:HSF1 is a transcription factor that enhances cancer formation and progression. Results:Cantharidin inhibited the binding of HSF1 to theHSP70promoter and subsequently blocked HSF1-dependentHSP70 expression. Conclusion:The HSF1-dependent expression of HSP70 and BAG3 is inhibited by cantharidin, causing the down-regulation of antiapoptotic BCL-2 family proteins, especially MCL-1. Significance:This information provides a new target molecule and pathway of cantharidin.

ISSN 

0021-9258

Link 

http://dx.doi.org/10.1074/jbc.M113.488346

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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