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Title 

Luteolin 8-C-β-fucopyranoside inhibits invasion and suppresses TPA-induced MMP-9 and IL-8 via ERK/AP-1 and ERK/NF-κB signaling in MCF-7 breast cancer cells

Authors 

S H ParkJ H KimD H LeeJ W KangHyuk Hwan SongSei-Ryang OhD Y Yoon

Publisher 

Elsevier

Issue Date 

2013

Citation 

Biochimie, vol. 95, no. 11, pp. 2082-2090

Keywords 

Breast cancerCancer invasionERKFlavonoidIL-8MMP-9

Abstract 

Matrix metalloproteinase 9 (MMP-9) and interleukin-8 (IL-8) play major roles in tumor progression and invasion of breast cancer cells. The present study was undertaken to investigate the inhibitory mechanism of cell invasion by luteolin 8-C-β-fucopyranoside (named as LU8C-FP), a C-glycosylflavone, in human breast cancer cells. We investigated whether LU8C-FP would inhibit MMP-9 activation and IL-8 expression in 12-O-tetradecanoylphorbol-13-acetate (TPA)-treated MCF-7 breast cancer cells. LU8C-FP suppressed TPA-induced MMP-9 and IL-8 secretion and mRNA expression via inhibition of the MAPK signaling pathway and down-regulation of nuclear AP-1 and NF-κB. TPA-induced phosphorylation of ERK 1/2 was suppressed by LU8C-FP, whereas JNK and p38 MAPK phosphorylation were unaffected. In addition, LU8C-FP blocked the ERK 1/2 pathways following expression of MMP-9 and IL-8. These results suggest LU8C-FP may function to suppress invasion of breast cancer cells through the ERK/AP-1 and ERK/NF-κB signaling cascades.

ISSN 

0300-9084

Link 

http://dx.doi.org/10.1016/j.biochi.2013.07.021

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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