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Title 

Synthesis and biological evaluation of ortho-carborane containing benzoxazole as an inhibitor of hypoxia inducible factor (HIF)-1 transcriptional activity

Authors 

H NakamuraY YasuiHyun Seung Ban

Publisher 

Elsevier

Issue Date 

2013

Citation 

Journal of Organometallic Chemistry, vol. 747, no. 0, pp. 189-194

Keywords 

BenzoxazilesHypoxia inducible factorInhibitionortho-CarboraneTranscription

Abstract 

ortho-Carborane and adamantane containing benzoxazoles were synthesized by intramolecular dehydration of the corresponding phenoxyacetanilides. Among the compounds synthesized, ortho-carborane containing benzoxazole 2b which has a carboxylic group on the benzoxazole ring, exhibited significant inhibition of hypoxia-induced HIF-1 transcriptional activity with the IC50 value of 14.4 μM toward HeLa cell-based reporter gene assay.

ISSN 

0022-328X

Link 

http://dx.doi.org/10.1016/j.jorganchem.2013.04.007

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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