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Title 

β-Arrestin 2 mediates G protein-coupled receptor 43 signals to Nuclear Factor-kappaB

 

베타어레스틴 2에 의한 GPR43-NFkB 신호전달계의 조절

Authors 

Su Ui LeeH J InM S KwonBi-oh ParkM JoMun-Ock KimSungchan ChoSangku LeeHyun Jun LeeY S KwakSunhong Kim

Publisher 

Pharmaceutical Society of Japan

Issue Date 

2013

Citation 

Biological & Pharmaceutical Bulletin, vol. 36, no. 11, pp. 1754-1759

Keywords 

β-arrestinG protein-coupled receptor 43InflammationNuclear factor-κB

Abstract 

G-protein coupled receptor 43 (GPR43) serves as a receptor for short-chain fatty acids (SCFAs), implicated in neutrophil migration and inflammatory cytokine production. However, the intracellular signaling pathway mediating GPR43 signaling remains unclear. Here, we show that β-arrestin 2 mediates the internalization of GPR43 by agonist. Agonism of GPR43 reduced the phosphorylation and nuclear translocation of nuclear factor-?B (NF-?B), which was relieved by short interfering RNA (siRNA) of β-arrestin 2. Subsequently, mRNA expression of proinflammatory cytokines, interleukin (IL)-6 and IL-1β, was downregulated by activation of GPR43 and knockdown of β-arrestin 2 recovered the expression of the cytokines. Taken together, these results suggest that GPR43 may be a plausible target for a variety of inflammatory diseases

ISSN 

0918-6158

Link 

http://dx.doi.org/10.1248/bpb.b13-00312

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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