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Title 

Acceleration of adipogenic differentiation via acetylation of malate dehydrogenase 2

Authors 

Eun Young KimBaek Soo HanWon Kon KimSang Chul LeeKwang-Hee Bae

Publisher 

Elsevier

Issue Date 

2013

Citation 

Biochemical and Biophysical Research Communications, vol. 441, no. 1, pp. 77-82

Keywords 

AcetylationAdipogenesisMDH2NADPHPTMs

Abstract 

Previously, we identified proteins showing a differential acetylation pattern during adipogenic differentiation. Here, we examined the role of malate dehydrogenase 2 (MDH2) acetylation in the adipogenesis of 3T3-L1 preadipocytes. The acetylation level of MDH2 showed a dramatic increase during adipogenesis. The overexpression of wild-type MDH2 induced the significant acceleration of adipogenic differentiation. On the other hand, the acetylation-block mutant MDH2 showed significantly reduced adipogenic differentiation compared to the wild type. MDH2 acetylation enhances its enzymatic activity and consequently intracellular NADPH level. These results suggest that the acetylation of MDH2 was affected by the cellular energy state and subsequently regulated adipogenic differentiation.

ISSN 

0006-291X

Link 

http://dx.doi.org/10.1016/j.bbrc.2013.10.016

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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