상세 정보

underline
Metadata Downloads : dc(xml) or Excel
Cited 0 time in scopus ci

Title 

Melatonin improves adriamycin-induced hepatic oxidative damage in rats

Authors 

I C LeeS H KimH S BaekC MoonC S BaeWoon Kee YoonKi Hoan NamHyoung-Chin KimJ C Kim

Publisher 

Korean Society of Toxicogenomics and Toxicoproteomic

Issue Date 

2013

Citation 

Molecular & Cellular Toxicology, vol. 9, no. 3, pp. 257-265

Keywords 

AdriamycinHepatotoxicityMelatoninOxidative stressProtective effects

Abstract 

The present study investigated the possible ameliorative effects of melatonin (MLT) against adriamycin (ADR)-induced hepatotoxicity and oxidative stress in rats. The following four experimental groups were evaluated: (1) vehicle control, (2) MLT (15 mg/kg/day), (3) ADR (10 mg/kg), and (4) ADR&MLT. ADR caused severe hepatotoxicity as evidenced by an elevation of serum aspartate aminotransferase and alanine aminotransferase activities, increased total bilirubin concentration, and decreased albumin and total protein concentration, indicating hepatic function abnormalities. Histopathological examination revealed various structural changes in liver, characterized by hepatocyte degeneration/necrosis, congestion, sinusoidal dilatation, vacuolation, and inflammatory cell infiltration. The significant decrease in reduced glutathione (GSH) content, catalase, superoxide dismutase (SOD), glutathione peroxidase (GPx), and glutathione reductase (GR) activities and the significant increase in malondialdehyde (MDA) content indicated that ADR-induced hepatotoxicity was mediated through oxidative stress. In contrast, MLT treatment significantly improved ADR-induced serum biochemical and histo-pathological alterations reflecting hepatic dysfunction. Moreover, MDA concentration and GSH content, GR, GPx, and SOD activities were not affected when MLT was administered in conjunction with ADR. These results indicated that MLT improved the oxidative damage induced by ADR in rat liver, presumably due to its ability to inhibit lipid peroxidation, and restore both enzymatic and nonenzymatic antioxidant activities.

ISSN 

1738-642X

Link 

http://dx.doi.org/10.1007/s13273-013-0033-0

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


There are no files associated with this item.
qrcode

FusionCharts.
DSpace Software Coptright(c) 2010 MIT and Hewleft-Packard  /  KRIBB-REPOSITORY ( Email:jakim@kribb.re.kr)