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Title 

Caspase-mediated cleavage and DNase activity of the translation initiation factor 3, subunit G (eIF3g)

Authors 

Jong-Tae KimSeon-Jin LeeBo Yeon KimChul Ho LeeYoung Il YeomYong Kyung ChoeD Y YoonS K ChaeJ W KimY YangJ S LimHee Gu Lee

Publisher 

Elsevier

Issue Date 

2013

Citation 

FEBS Letters, vol. 587, no. 22, pp. 3668-3674

Keywords 

ApoptosisCaspaseDNaseeIF3gTranslation initiation factor

Abstract 

Eukaryotic translation initiation factor 3 is composed of 13 subunits (eIF3a through eIF3m) and plays an essential role in translation. During apoptosis, several caspases rapidly down-regulate protein synthesis by cleaving eIF4G, -4B, -3j, and -2α. In this study, we found that the activation of caspases by cisplatin in T24 cells induces the cleavage of subunit G of the eIF3 complex (eIF3g). The cleavage site (SLRD220G) was identified, and we found that the cleaved N-terminus was translocated to the nucleus, activating caspase-3, and that it also showed a strong DNase activity. These data demonstrate the important roles of eIF3g in the translation initiation machinery and in DNA degradation during apoptosis.

ISSN 

0014-5793

Link 

http://dx.doi.org/10.1016/j.febslet.2013.09.027

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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