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Title 

A new phenanthrene derivative and two diarylheptanoids from the roots of Brassica rapa ssp. campestris inhibit the growth of cancer cell lines and LDL-oxidation

Authors 

Q WuJ G ChoK H YooTae Sook JeongJ H ParkS Y KimJ H KangI S ChungM S ChoiK T LeeH G ChungM H BangN I Baek

Publisher 

Pharmaceutical Society of Korea

Issue Date 

2013

Citation 

Archives of Pharmacal Research, vol. 36, no. 4, pp. 423-429

Keywords 

6-ParadolBrassica rapa ssp. campestrisBrassicaphenanthrene AHCT-116HeLaLow density lipoproteinMCF-7trans-6-Shogaol

Abstract 

Brassica rapa ssp. campestris (Brassicaceae) is a conical, deep purple, edible root vegetable commonly known as a turnip. We initiated phytochemical and pharmacological studies to search for biological active compounds from the roots of B. rapa ssp. campestris. We isolated a novel phenanthrene derivative, 6-methoxy-1-[10-methoxy-7-(3-methylbut-2-enyl)phenanthren-3-yl]undecane-2, 4-dione, named brassicaphenanthrene A (3) along with two known diarylheptanoid compounds, 6-paradol (1) and trans-6-shogaol (2), through the repeated silica gel (SiO2), octadecyl silica gel, and Sephadex LH-20 column chromatography. The chemical structures of the compounds were determined by spectroscopic data analyses including nuclear magnetic resonance, mass spectrometry, ultraviolet spectroscopy, and infra-red spectroscopy. All compounds exhibited high inhibitory activity against the growth of human cancer lines, HCT-116, MCF-7, and HeLa, with IC50 values ranging from 15.0 to 35.0 μM and against LDL-oxidation with IC50 values ranging from 2.9 to 7.1 μM.

ISSN 

0253-6269

Link 

http://dx.doi.org/10.1007/s12272-013-0068-8

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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