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Title 

Carbohydrate derivatives from the roots of Brassica rapa ssp. campestris and their effects on ROS production and glutamate-induced cell death in HT-22 cells

Authors 

Q WuJ G ChoD S LeeD Y LeeN Y SongY C KimK T LeeH G ChungM S ChoiTae Sook JeongE M AhnG S KimN I Baek

Publisher 

Elsevier

Issue Date 

2013

Citation 

Carbohydrate Research, vol. 372, no. 0, pp. 9-14

Keywords 

3,7-Anhydro-1-deoxy-d-glycero-d-gulo-2-octuloseBrassica rapa ssp. campestrisEthanone-1-C-β-d- glucopyranosideReactive oxygen speciesSucrose 3,3′,4′-triisovalerateSucrose 6,3′,4′-triisovalerate

Abstract 

Phytochemical investigation of the roots of Brassica rapa ssp. campestris led to the isolation of three new carbohydrate derivatives, namely sucrose 3,3′,4′-triisovalerate (2), sucrose 6,3′,4′- triisovalerate (3), and ethanone-1-C-β-d-glucopyranoside (3,7-anhydro-1-deoxy-d-glycero-d-gulo-2-octulose, 6), along with four known carbohydrate derivatives, 2,6,3′,4′-tetraisovalerate (1), ethyl β-d-glucopyranoside (4), n-butyl β-d-fructofuranoside (5), and n-pentyl β-d-fructofuranoside (7), which were initially isolated from plants of the Brassica genus. Structures of the isolated compounds were established by spectroscopic analyses, including UV, IR, MS, and NMR. All of the isolated carbohydrate derivatives were evaluated to determine their effect on ROS production and glutamate-induced cell death in HT-22 cells. Compound 6 showed the most significant ROS reduction and a protective effect with IC 50 values of 69.4 ± 3.8 μM and 4.96 ± 0.32 μM, respectively, which were equivalent to those of the positive control, Trolox.

ISSN 

0008-6215

Link 

http://dx.doi.org/10.1016/j.carres.2012.09.015

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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