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Title 

Vitamin D3 up-regulated protein 1 controls the priming phase of liver regeneration

 

VDUP1의 간 재생에서의 priming phase 조절

Authors 

H J KwonSung Kuk HongWoon Kee YoonKi Hoan NamIn Pyo ChoiD Y KimHyoung-Chin KimYoung Suk Won

Publisher 

The Korean Society of Veterinary Science

Issue Date 

2013

Citation 

Journal of Veterinary Science, vol. 14, no. 3, pp. 257-262

Keywords 

C-Jun-N-terminal kinaseNF-κBPartial hepatectomySignal transducer and activator of transcription 3Vitamin D3 up-regulated protein 1

Abstract 

Vitamin D3 up-regulated protein 1 (VDUP1) is a potent growth suppressor that inhibits tumor cell proliferation and cell cycle progression when overexpressed. In a previous study, we showed that VDUP1 knockout (KO) mice exhibited accelerated liver regeneration because such animals could effectively control the expression of cell cycle regulators that drive the G1-to-S phase progression. In the present study, we further investigated the role played by VDUP1 in initial priming of liver regeneration. To accomplish this, VDUP1 KO and wild-type (WT) mice were subjected to 70% partial hepatectomy (PH) and sacrificed at different times after surgery. The hepatic levels of TNF-α and IL-6 increased after PH, but there were no significant differences between VDUP1 KO and WT mice. Nuclear factor-κB (NF-κB), c-Jun-N-terminal kinase (JNK), and signal transducer and activator of transcription 3 (STAT-3) were activated much earlier and to a greater extent in VDUP1 KO mice after PH. A single injection of TNF-α or IL-6 caused rapid activation of JNK and STAT-3 expression in both mice, but the responses were stronger and more sustained in VDUP1 KO mice. In conclusion, our findings provide evidence that VDUP1 plays a role in initiation of liver regeneration.

ISSN 

1229-845X

Link 

http://dx.doi.org/10.4142/jvs.2013.14.3.257

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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