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Title 

Interference with the mitochondrial bioenergetics fuels reprogramming to pluripotency via facilitation of the glycolytic transition

Authors 

Myung Jin SonB R JeongYooJeong KwonYee Sook Cho

Publisher 

Elsevier

Issue Date 

2013

Citation 

International Journal of Biochemistry & Cell Biology, vol. 45, no. 11, pp. 2512-2518

Keywords 

BioenergeticsGlycolysisiPSCsMitochondriaReprogramming

Abstract 

The switch in cell metabolism from oxidative phosphorylation to glycolysis is critical for the reprogramming of cells to pluripotency. Here, we demonstrate that the disturbance of mitochondrial metabolism by canonical mitochondrial inhibitors enhances metabolic reprogramming toward a glycolytic state, enabling the highly efficient generation of induced pluripotent stem cells. This interference with mitochondrial bioenergetics resulted in enriched reprogrammable subpopulations and accelerated the conversion of refractory intermediates to pluripotent states without requiring additional genetic or epigenetic modifications. Conversely, the reprogramming efficiency and accelerated reprogramming kinetics promoted by mitochondrial inhibition were obstructed by glycolysis inhibitors. We suggest that changes in mitochondrial bioenergetics are a novel mechanism involved in the regulation of cell fate and, more importantly, in the reprogramming of cells to pluripotency.

ISSN 

1357-2725

Link 

http://dx.doi.org/10.1016/j.biocel.2013.07.023

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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