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Title 

Bisabolangelone inhibits dendritic cell functions by blocking MAPK and NF-kappa B signaling

Authors 

H S KimY J LeeH K LeeJ S KimY ParkJong Soon KangB Y HwangJ T HongY KimS B Han

Publisher 

Elsevier

Issue Date 

2013

Citation 

Food and Chemical Toxicology, vol. 59, no. 0, pp. 26-33

Keywords 

BisabolangeloneDendritic cellsMAPKsNF-κB

Abstract 

Bisabolangelone (BISA), isolated from the roots of Angelica koreana, has many pharmacological activities, such as anti-tumor, anti-microbial, antioxidant, and anti-inflammatory activities. In this study, we investigated the anti-inflammatory mechanisms of BISA in dendritic cells (DCs), which play an essential role in innate and adaptive immune responses. BISA attenuated the production of pro-inflammatory cytokines including interleukin (IL)-12, IL-1β, and tumor necrosis factor-alpha (TNF-α), migration to macrophage inflammatory protein-3 beta, and allo-T cell activating ability of DCs. In addition, BISA affected endocytosis of DCs. Molecular studies showed that BISA suppressed MAPK phosphorylation and nuclear translocation of NF-κB p50/p65. Taken together, our data suggest that BISA inhibited DC functions by blocking MAPK and NF-κB signaling.

ISSN 

0278-6915

Link 

http://dx.doi.org/10.1016/j.fct.2013.05.013

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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