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Title 

Why do the abundances of ions generated by MALDI look thermally determined?

Authors 

Y J BaeJ C ChoeJeong Hee MoonM S Kim

Publisher 

Elsevier

Issue Date 

2013

Citation 

Journal of American Society for Mass Spectrometry, vol. 24, no. 11, pp. 1807-1815

Keywords 

AutoprotolysisMALDIPrimary ion formationRecombinationThermal determination

Abstract 

In a previous study (J. Mass Spectrom. 48, 299-305, 2013), we observed that the abundance of each ion in a matrix-assisted laser desorption ionization (MALDI) spectrum looked thermally determined. To find out the explanation for the phenomenon, we estimated the ionization efficiency and the reaction quotient (QA) for the autoprotolysis of matrix, M + M → [M + H] + + [M - H]-, from the temperature-controlled laser desorption ionization spectra of α-cyano-4-hydroxycinnamic acid (CHCA) and 2,5-dihydroxybenzoic acid (DHB). We also evaluated the equilibrium constants (KA) for the autoprotolysis at various temperatures by quantum chemical calculation. Primary ion formation via various thermal models followed by autoprotolysis-recombination was compatible with the observations. The upper limit of the effective temperature of the plume where autoprotolysis- recombination occurs was estimated by equating QA with the calculated equilibrium constant. [

ISSN 

1044-0305

Link 

http://dx.doi.org/10.1007/s13361-013-0717-7

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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