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Title 

Cell-cell communication via extracellular membrane vesicles and its role in the immune response

Authors 

Hwang In Kyu

Publisher 

Springer Verlag (Germany)

Issue Date 

2013

Citation 

Molecules and Cells, vol. 36, no. 2, pp. 105-111

Keywords 

ectosomeexosomeimmunityintercellular communicationvaccine

Abstract 

The host immune response involves a variety of cell types, including specialized immune and non-immune cells. The delicate coordination among these cells via close communication is central for the proper operation of immune system. Cell-cell communication is mediated by a complex network that includes soluble factors such as cytokines, chemokines, and metabolites exported from cells, as well as membrane-bound receptors and their ligands. Cell-cell communication is also mediated by membrane vesicles (e.g., exosomes, ectosomes), which are either shed by distant cells or exchanged by cells that are making direct contact. Intercellular communication via extracellular membrane vesicles has drawn much attention recently, as they have been shown to carry various biomolecules that modulate the activities of recipient cells. In this review, I will discuss current views on cell-cell communication via extra-cellular membrane vesicles, especially shedded membrane vesicles, and their effects on the control of the immune system.

ISSN 

1016-8478

Link 

http://dx.doi.org/10.1007/s10059-013-0154-2

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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