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Title 

A novel canine influenza H3N2 virus isolated from cats in an animal shelter

Authors 

H Y JeoungS I LimB H ShinJ A LimJ Y SongDae Sub SongB K KangH J MoonD J An

Publisher 

Elsevier

Issue Date 

2013

Citation 

Veterinary Microbiology, vol. 165, no. 3, pp. 281-286

Keywords 

CIVFelineH3N2

Abstract 

The interspecies transmission of avian-origin H3N2 canine influenza virus (CIV) to dogs was first reported in 2007. The present study characterized a novel CIV H3N2 isolated from cats in an animal shelter. A comparative analysis of the deduced amino acid sequences of the A/Canine/Korea/CY009/2010(H3N2) (CY009) and A/Feline/Korea/FY028/2010 (H3N2) (FY028) strains isolated from dogs and cats, respectively, in the animal shelter identified point mutations in 18 amino acid positions within eight viral genes. Interestingly, CY009 and FY028 replicated well in specific pathogen-free embryonated chicken eggs and in mice, respectively. Mice infected with the FY028 strain exhibited significant over expression of IL-10, TNF-α, and IFN-γ (p < 0.001) at 3 days postinfection. Thus, an emergency monitoring system should be developed to identify influenza mutations that occur during interspecies transmission in companion animals and for continuous public health surveillance.

ISSN 

0378-1135

Link 

http://dx.doi.org/10.1016/j.vetmic.2013.03.021

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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