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Title 

Shiga toxins expressed by human pathogenic bacteria induce immune responses in host cells

 

숙주내에서 면역반응을 유도하는 인간병원체 박테리아로부터 배출되는 시가독소

Authors 

Moo Seung LeeMyung Hee KimV L Tesh

Publisher 

Microbiological Society of Korea

Issue Date 

2013

Citation 

Journal of Microbiology, vol. 51, no. 6, pp. 711-716

Keywords 

animal modelHUSinflammatory responseShiga toxinsignaling

Abstract 

Shiga toxins are a family of genetically and structurally related toxins that are the primary virulence factors produced by the bacterial pathogens Shigella dysenteriae serotype 1 and certain Escherichia coli strains. The toxins are multifunctional proteins inducing protein biosynthesis inhibition, ribotoxic and ER stress responses, apoptosis, autophagy, and inflammatory cytokine and chemokine production. The regulated induction of inflammatory responses is key to minimizing damage upon injury or pathogen-mediated infections, requiring the concerted activation of multiple signaling pathways to control cytokine/chemokine expression. Activation of host cell signaling cascades is essential for Shiga toxin-mediated proinflammatory responses and the contribution of the toxins to virulence. Many studies have been reported defining the inflammatory response to Shiga toxins in vivo and in vitro, including production and secretion of tumor necrosis factor alpha (TNF-α), interleukin-1β (IL-1β), macrophage inflammatory protein-1α/β (MIP-1α/β), macrophage chemoattractant monocyte chemoattractant protein 1 (MCP-1), interleukin 8 (IL-8), interleukin 6 (IL-6), and Groβ. These cytokines and chemokines may contribute to damage in the colon and development of life threatening conditions such as acute renal failure (hemolytic uremic syndrome) and neurological abnormalities. In this review, we summarize recent findings in Shiga toxin-mediated inflammatory responses by different types of cells in vitro and in animal models. Signaling pathways involved in the inflammatory responses are briefly reviewed.

ISSN 

1225-8873

Link 

http://dx.doi.org/10.1007/s12275-013-3429-6

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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