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Title 

Inhibitory effects of Pycnogenol (French maritime pine bark extract) on airway inflammation in ovalbumin-induced allergic asthma

Authors 

In Sik ShinNa Rae ShinChan Mi JeonJu Mi HongOk-Kyoung KwonJ C KimSei-Ryang OhK W HahnKyung Seop Ahn

Publisher 

Elsevier

Issue Date 

2013

Citation 

Food and Chemical Toxicology, vol. 62, no. 0, pp. 681-686

Keywords 

AsthmaFrench maritime pine barkInflammationPycnogenol®

Abstract 

Pycnogenol® (PYC) is a standardized extracts from French maritime pine bark.?PYC reduced proinflammatory mediator in LPS-stimulated RAW264.7 cells.?PYC attenuated airway inflammation in allergic asthma murine model.?PYC decreased the expression of MMP-9 and iNOS in both in vivo and in vitro.?PYC overexpressed HO-1 in both in vivo and in vitro. Pycnogenol® (PYC) is a standardized extracts from the bark of the French maritime pine (Pinus maritime) and used as a herbal remedy for various diseases. In this study, we evaluated the effects of PYC on airway inflammation using a model of ovalbumin (OVA)-induced allergic asthma and RAW264.7 cells. PYC decreased nitric oxide production and reduced the interleukine (IL)-1β and IL-6 levels in LPS-stimulated RAW264.7 cells. PYC also reduced the expression of inducible nitric oxide synthase (iNOS) and matrix metalloproteinase (MMP)-9 and enhanced the expression of hemeoxygenase (HO)-1. In the in vivo experiment, PYC decreased the inflammatory cell count and the levels of IL-4, IL-5, IL-13, and immunoglobulin (Ig) E in BALF or serum. These results are consistent with the histological analysis findings, which showed that PYC attenuated the airway inflammation and mucus hypersecretion induced by OVA challenge. In addition, PYC enhanced the expression of HO-1. In contrast, PYC inhibited the elevated expression of iNOS and MMP-9 proteins induced by OVA challenge. In conclusion, PYC exhibits protective effects against OVA-induced asthma and LPS-stimulated RAW264.7 cells. These results suggest that PYC has potential as a therapeutic agent for the treatment of allergic asthma.

ISSN 

0278-6915

Link 

http://dx.doi.org/10.1016/j.fct.2013.09.032

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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