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Title 

Protein tyrosine phosphatase profiling studies during brown adipogenic differentiation of mouse primary brown preadipocytes

Authors 

Hye-Ryung ChoiWon Kon KimAnna ParkHyeyun JungBaek Soo HanSang Chul LeeKwang-Hee Bae

Publisher 

Korean Society for Biochemistry and Molecular Biology

Issue Date 

2013

Citation 

BMB Reports, vol. 46, no. 11, pp. 539-543

Keywords 

AdipogenesisBrown adipocytesDusp12ObesityProtein tyrosine phosphatases

Abstract 

There is a correlation between obesity and the amount of brown adipose tissue; however, the molecular mechanism of brown adipogenic differentiation has not been as extensively studied. In this study, we performed a protein tyrosine phosphatase (PTP) profiling analysis during the brown adipogenic differentiation of mouse primary brown preadipocytes. Several PTPs, including PTPRF, PTPRZ, and DUSP12 showing differential expression patterns were identified. In the case of DUSP12, the expression level is dramatically downregulated during brown adipogenesis. The ectopic expression of DUSP12 using a retroviral expression system induces the suppression of adipogenic differentiation, whereas a catalytic inactive DUSP12 mutant showed no effect on differentiation. These results suggest that DUSP12 is involved in brown adipogenic differentiation and may be used as a target protein for the treatment or prevention of obesity by the regulation of brown adipogenic differentiation.

ISSN 

1976-6696

Link 

http://dx.doi.org/10.5483/BMBRep.2013.46.11.058

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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