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Title 

CD27 engagement by a soluble CD70 protein enhances non-cytolytic antiviral activity of CD56bright natural killer cells by IFN-γ secretion

Authors 

Y S JangW KangD Y ChangP S SungBum Chan ParkS H YooYoung Woo ParkE C Shin

Publisher 

Elsevier

Issue Date 

2013

Citation 

Clinical Immunology, vol. 149, no. 3, pp. 379-387

Keywords 

CD27CD70Hepatitis C virusIFN-γNatural killer cells

Abstract 

We investigated regulation of human NK cell function by CD27 engagement using a recombinant soluble CD70 protein. CD27 was preferentially expressed on CD56bright NK cells, and soluble CD70 protein bound to CD27+CD56bright NK cells. While soluble CD70 protein enhanced IFN-γ secretion by CD56bright NK cells in the presence of IL-12, it augmented neither cytolytic activity nor proliferation of NK cells. Thus, we next asked if soluble CD70 protein could be used to induce non-cytolytic antiviral activity of NK cells using an in vitro hepatitis C virus (HCV) infection system. Soluble CD70 protein stimulated NK cells to suppress HCV replication by enhancing NK cell IFN-γ secretion without killing infected cells. Taken together, we demonstrate that CD27 engagement by a soluble CD70 protein enhances non-cytolytic antiviral activity of CD56bright NK cells by IFN-γ secretion. Thus, this soluble CD70 protein may be useful for the treatment of viral infections such as HCV infection.

ISSN 

1521-6616

Link 

http://dx.doi.org/10.1016/j.clim.2013.09.007

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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