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Title | CD27 engagement by a soluble CD70 protein enhances non-cytolytic antiviral activity of CD56bright natural killer cells by IFN-γ secretion |
Authors | Y S Jang; W Kang; D Y Chang; P S Sung; Bum Chan Park; S H Yoo; Young Woo Park; E C Shin |
Publisher | Elsevier |
Issue Date | 2013 |
Citation | Clinical Immunology, vol. 149, no. 3, pp. 379-387 |
Keywords | CD27; CD70; Hepatitis C virus; IFN-γ; Natural killer cells |
Abstract | We investigated regulation of human NK cell function by CD27 engagement using a recombinant soluble CD70 protein. CD27 was preferentially expressed on CD56bright NK cells, and soluble CD70 protein bound to CD27+CD56bright NK cells. While soluble CD70 protein enhanced IFN-γ secretion by CD56bright NK cells in the presence of IL-12, it augmented neither cytolytic activity nor proliferation of NK cells. Thus, we next asked if soluble CD70 protein could be used to induce non-cytolytic antiviral activity of NK cells using an in vitro hepatitis C virus (HCV) infection system. Soluble CD70 protein stimulated NK cells to suppress HCV replication by enhancing NK cell IFN-γ secretion without killing infected cells. Taken together, we demonstrate that CD27 engagement by a soluble CD70 protein enhances non-cytolytic antiviral activity of CD56bright NK cells by IFN-γ secretion. Thus, this soluble CD70 protein may be useful for the treatment of viral infections such as HCV infection. |
ISSN | 1521-6616 |
Link | |
Appears in Collections | |
Registered Date |
2019-05-02 |
