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Title 

The involvement of Nrf2 in the protective effects of diallyl disulfide on carbon tetrachloride-induced hepatic oxidative damage and inflammatory response in rats

Authors 

I C LeeS H KimH S BaekC MoonS S KangY B KimIn Sik ShinJ C Kim

Publisher 

Elsevier

Issue Date 

2014

Citation 

Food and Chemical Toxicology, vol. 63, no. 1, pp. 174-185

Keywords 

Carbon tetrachlorideDiallyl disulfideHepatotoxicityNuclear factor E2-related factor 2Nuclear factor kappaB

Abstract 

This study investigated the potential effect of diallyl disulfide (DADS) against carbon tetrachloride (CCl4)-induced oxidative hepatic damage and inflammatory response in rat liver. DADS at doses of 50 and 100mg/kg/day was administered orally once daily for 5days, prior to CCl4 administration. Pretreatment with DADS attenuated CCl4-induced elevated serum transaminase activities and histopathological alterations in liver. It prevented the hepatocellular apoptotic changes with induction of Bcl-2-associated X (Bax), cytochrome c, and caspase-3 caused by CCl4. An increase in the nuclear translocation of nuclear factor-kappaB (NF-κB) and phosphorylation of I kappaB alpha (IκBα) was observed in the livers of CCl4-treated rats that coincided with induction of inflammatory mediators or cytokines. In contrast, DADS inhibited NF-κB translocation and IκBα phosphorylation, and that subsequently decreased inflammatory mediators. Furthermore, DADS prevented CCl4-induced depletion of cytosolic nuclear factor E2-related factor 2 (Nrf2) and suppression of nuclear translocation of Nrf2, which, in turn, up-regulated phase II/antioxidant enzyme activities. Taken together, these results demonstrate that DADS increases the expression of phase II/antioxidant enzymes and simultaneously decreases the expression of inflammatory mediators in CCl4-induced liver injury. These findings indicate that DADS induces antioxidant defense mechanism by activating Nrf2 pathway and reduces inflammatory response by inhibiting NF-κB activation.

ISSN 

0278-6915

Link 

http://dx.doi.org/10.1016/j.fct.2013.11.006

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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